4+ day, 3+ hour ago   (235+ words) Lotus Neuro, a clinical-stage biotechnology company spun out of focused ultrasound specialist Insightec, launched publicly with a platform designed to improve delivery of therapeutics across the blood-brain barrier (BBB). The underlying Insightec technology has already been evaluated clinically in several…...

4+ day, 20+ hour ago   (464+ words) AllSci A Nature publication has given South San Francisco-based Apeximmune Therapeutics substantial external validation, with two independent research teams converging on the same immune checkpoint target — phospholipase A2 group IID (PLA2G2D) — as a mechanism underlying resistance to anti-PD-1 therapy. The convergence, achieved…...

4+ day, 22+ hour ago   (500+ words) AllSci Researchers at the University of California, Davis have used systematic chemical deconstruction of lysergic acid diethylamide (LSD) to identify which features of its complex molecular architecture are required to produce its characteristic activity at serotonin receptors — findings the authors…...

5+ day, 21+ hour ago   (198+ words) In HEK293T cells, STV-C8 required more than 10,000-fold less mRNA than LNPs formulated with the clinical ionizable lipid ALC-0315 to achieve equivalent reporter expression. The platform also delivered RNA into primary human monocytes, retinal organoids, and mouse astrocytes, cell types in…...

1+ week, 5+ day ago   (449+ words) AllSci South Korea-based Pharos iBio and Kolon Pharma have signed a joint research and development agreement to co-develop PHI-701, a preclinical EGFR-targeting small molecule candidate for non-small cell lung cancer (NSCLC), converting a memorandum of understanding (MOU) signed in May…...

2+ week, 5+ day ago   (386+ words) AllSci UK-based 4basebio PLC (AIM: 4BB) and Indianapolis-based Genezen, a gene therapy contract development and manufacturing organization (CDMO), announced a non-exclusive commercial collaboration integrating 4basebio's cell-free synthetic DNA platform into Genezen's viral vector manufacturing workflow, giving gene therapy developers access to research-use-only,…...

2+ week, 6+ day ago   (132+ words) The spine MRI monitoring program that identified the findings was itself implemented in response to an earlier clinical hold related to RGX-111, RegenxBio's investigational gene therapy for MPS I. That expanded monitoring protocol — covering both brain and spine MRI — was the…...

3+ week, 36+ min ago   (144+ words) A Boehringer Ingelheim Phase I multiple rising dose trial evaluating the investigational oral CNS compound BI 3031185 has been suspended following a safety event, according to an update to ClinicalTrials.gov. The registry does not disclose the nature of the event,…...

3+ week, 2+ hour ago   (268+ words) AllSci University of Rochester has received a USD 2.38 million NIH R01 grant from the National Heart, Lung, and Blood Institute (NHLBI) to investigate how protein kinase D3 (PKD3) regulates endothelial-to-mesenchymal transition (EndMT) in mitral valve prolapse (MVP), a valvular heart condition. The award,…...

3+ week, 2+ day ago   (227+ words) China-based Akeso (HKEX: 9926) has received clearance from China's National Medical Products Administration (NMPA) to initiate a Phase I study of AK157D1, a B7-H3-targeting antibody-drug conjugate (ADC), in patients with advanced solid tumors. The clearance makes AK157D1 the third ADC from Akeso's internal…...