A new review details how tumor cells import, export and steal mitochondria through nanotubes and vesicles to fuel growth, exhaust T cells and resist therapy.
New research shows the immune protein perforin can kill tumor cells on its own by triggering iron-dependent ferroptosis, even when the major granzymes are missing. For decades, immunologists have taught a tidy division of labor inside the immune system's most…
A new review details how gold nanoparticles can simultaneously enhance cancer imaging, deliver chemotherapy drugs and destroy tumors with heat in preclinical studies.
Cancer Research UK Clinical Trials Unit, Leeds Institute of Clinical Trial Research, University of Leeds, United Kingdom Institute of Biomedicine and Molecular Genetics (IBGM), Higher Council for Scientific Research (CSIC) - University of Valladolid (UVA), Spain Institute of Organ Transplantation, Sichuan…
A new review finds that the circular RNA circ_0000285 is overexpressed in most studied cancers, where it promotes growth and metastasis through miRNA sponging, while it is suppressed in bladder cancer. Subject of Research: The roles and pathways of the circular…
A new Fc-free CLDN18.2 × CD3 bispecific antibody called AHT-102 showed dose-dependent tumor suppression, tumor-selective tissue distribution, and no systemic immunotoxicity in preclinical mouse models. AHT-102 was engineered specifically to address these limitations through two structural choices: the removal of the Fc region…
A nanoscale particle with a unique structure, developed at MIT, holds potential as a customizable delivery vehicle for personalized cancer vaccines. The backbone of the vaccine is a modified, harmless bacteriophage called M13, which forms a nanofiber that can be coated…
A review in Cellular Oncology proposes that tumor blood vessels actively regulate antitumor immunity through angiocrine, metabolic and structural mechanisms. Tumor blood vessels do far more than deliver oxygen and nutrients to growing cancers A review published in Cellular Oncology…
A newly cloned fungal immunomodulatory protein from Ganoderma cf. resinaceum shows stimulus-dependent immune enhancement in macrophages and antiproliferative effects in breast cancer cell lines. News Source: Gregory Coleman. (October 30, 2026). Novel Ganoderma protein shows dual immune and anticancer activity in cell…
• siRNA versus ASOs — For pure gene silencing, siRNA offers better durability, deeper knockdown and cleaner safety, while ASOs still matter w... The future of RNAi with Arrowhead’s Chris Anzalone on The BioCentury Show CEO’s view on solving extra-hepatic siRNA delivery…
mRNA platforms, boosters, monoclonals, and immune‑system science.
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