LC–MS/MS emerges as the workhorse of modern drug development
A new review maps how liquid chromatography–tandem mass spectrometry now quantifies drugs, metabolites, genotoxic impurities and proteins across every stage of pharmaceutical development.
A new review maps how liquid chromatography–tandem mass spectrometry now quantifies drugs, metabolites, genotoxic impurities and proteins across every stage of pharmaceutical development.
A new open-access protocol uses continuous dynamic light scattering to track protein self-assembly minute by minute, with the full workflow completed in roughly eight hours.
Stanford researchers validated a rapidly tunable UV laser fluorescence technique that measures temperature and pressure in shock tube flows from 295 to 1350 kelvin with average errors of 3.0 and 5.5 percent.
A simulated copper, tin disulfide, and molybdenum ditelluride SPR sensor reached a modeled sensitivity of 142.15 degrees per refractive index unit for distinguishing the refractive indices of brain tumor tissues, though experimental validation is still lacking.
Newswise — Some of the most important discoveries in materials science and structural biology come down to a simple question: where, exactly, are the atoms- The arrangement of atoms determines nearly everything about how a material behaves in the real world…
A pilot study combined broadband coherent Raman imaging of head and neck cancer tissue from five patients with a high-speed setup reaching 134-microsecond pixel dwell times, achieving 62 percent classification accuracy in a proof-of-concept model. Subject of Research: Broadband coherent Raman…
A new imaging technique allows scientists to capture fleeting cellular processes that conventional microscopes struggle to resolve. Super-resolution microscopy has transformed cell biology by revealing structures that conventional light microscopes cannot clearly distinguish. Many established techniques rely on fluorescent molecules…
A compact single-capture 3D imaging system originally developed for aesthetic medicine produced photorealistic, metrically scaled models of simulated face and neck injuries in under one second of acquisition, though formal validation remains outstanding. Subject of Research: Technical feasibility of adapting a…
Searching for the mechanism, the investigators found that loss of Myc lowered both the mRNA and protein levels of genes encoding glycerophospholipid metabolic enzymes in the granulosa cells. Metabolite measurements matched this enzymatic downshift: knockout of Myc reduced the pool…
The CW-MHF Mid-IR Laser is ideal for high-resolution mid-IR spectroscopy. If users require excellent spectral resolution, phase-continuous tuning to avoid hopping across spectral lines, or both, the DRS Daylight CW-Mode-Hop-Free laser will fulfill those requirements. Narrow-linewidth operation and MHF tuning…
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