NASHVILLE, Tenn. — The dual-acting interleukin-23 inhibitor guselkumab improved histologic outcomes in patients with moderately to severely active ulcerative colitis over a 3-year span, according to a presenter here. While some clinical trials have shown histologic outcomes in patients with UC, researchers…
Scientists exploring the links between a spinal cord injury, inflammation and immune function have turned their attention to a genome-level analysis of the gut microbial community, with early study results offering hints at potential new approaches to aid healing. In…
A retrospective cohort of 199 pulmonary mycosis patients on triazole antifungals identified baseline liver enzymes and immunocompromised status as risk factors for liver injury, while integrative analysis flagged KDR as a candidate shared hepatotoxicity target. Elevated baseline levels of the liver…
A two-center study reports that a random forest model using five bacterial species detected by probe capture-based metagenomic sequencing classified Nugent-defined bacterial vaginosis with an internal AUC of 0.939 and an external AUC of 0.843.
The gut bacterium Blautia sp. MRG-PMF1 uses a cobalamin-dependent O-demethylase to cleave ethyl, propyl and isopropyl ether groups from isoflavone derivatives, converting them to 7-hydroxyisoflavone through an SN2-type mechanism.
A new study shows that stress triggers an early intestinal ROS burst that suppresses short-chain fatty acid production, erodes the gut's hypoxic barrier and enables pathobiont enrichment in zebrafish and mice.
A new review proposes the MMCK syndrome, an operational extension of the CKM framework that integrates MASLD liver fibrosis scoring into multi-organ cardiometabolic-renal risk assessment. News Source: Ophelia Keating. (October 30, 2026). Scientists Propose MMCK Syndrome to Put the Liver at the…
A new review links gut microbial imbalances to Alzheimer's, Parkinson's, Huntington's and ALS through inflammation, metabolites and the gut–brain axis. Gut microbes linked to Alzheimer's, Parkinson's, Huntington's and ALS Subject of Research: The role of the human gut microbiome…
A combined Mendelian randomization, SMR and mediation analysis links genetically predicted GLS expression to higher irritable bowel syndrome risk, partly mediated by mannose, mannonate and glycerophospholipid changes. Subject of Research: Genetic and mediation analysis of the succinylation-related gene GLS and…
Variants in vitamin D metabolism genes VDR and NADSYN1 are associated with lower gut microbial diversity and altered bacterial abundance in postmenopausal women. Subject of Research: Associations between vitamin D metabolism gene variants and gut microbiota diversity in postmenopausal women Article…
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