23+ hour, 21+ min ago   (250+ words) Researchers at Duke University School of Medicine have developed an artificial intelligence framework that can redesign proteins on a scale previously seen only in natural evolution. The tool can create shorter, longer, and highly modified versions of proteins while preserving…...

1+ day, 1+ hour ago   (714+ words) Cell segmentation is challenging in spatial biology primarily because dense, morphologically heterogeneous tissue sections bear no resemblance to the sparse, uniformly lit cell cultures on which early segmentation algorithms were trained. In tissue, cells are densely packed and frequently in…...

1+ day, 5+ hour ago   (351+ words) For nearly a decade, the Cancer Dependency Map, or DepMap, at the Broad Institute has helped scientists uncover new cancer dependencies — the genetic changes some cancers need to thrive that can potentially be targeted by new cancer drugs. The study…...

1+ day, 6+ hour ago   (10+ words) Technology Networks...

2+ day, 1+ hour ago   (321+ words) “Right now, everybody gets the same dose,” says Joyita Dutta, professor in the Riccio College of Engineering at UMass Amherst. “That essentially leaves the therapy’s potential untapped, to the extent that it’s suboptimal for a given patient. Measuring how much…...

2+ day, 1+ hour ago   (344+ words) At the level of detection physics, multiplexed tissue imaging methods divide into two classes: those that use optical fluorescence readouts and those that use mass spectrometry to quantify metal-tagged antibodies. Figure 1: A two-panel schematic contrasting cyclic fluorescence imaging (stain, image,…...

3+ day, 6+ hour ago   (1536+ words) The majority of lead compounds fail before they become valid candidates for preclinical testing. Of the candidates that do make it to the preclinical stage, most will never reach clinical trials. And of those that enter human studies, only one…...

4+ day, 10+ hour ago   (1143+ words) Laboratories are generating more data than ever before, yet much of that information remains fragmented across disconnected instruments, software platforms, and legacy systems. While many organizations have invested heavily in digitization, simply connecting systems is not enough to unlock the…...

6+ day, 21+ hour ago   (91+ words) A structured approach to antibody panel design applies across both fluorescence and mass-based platforms: Table 1: Major multiplexed tissue imaging platforms used in spatial proteomics and their principal characteristics. Up to 60 markers or more 40 or more markers ~1 µm (subcellular with high-res…...

6+ day, 23+ hour ago   (639+ words) Researchers at Yale School of Medicine have conducted the first comprehensive structural analyses of a class of proteins whose dysfunction is associated with neurodegenerative diseases. In two new studies published in Cell and Molecular Cell, researchers investigated, at the atomic…...