News
Digital Tools Benefits Lauded by U.K. Cell and Gene Therapy Accelerator
2+ hour, 7+ min ago (507+ words) By Vivienne Raper, PhD A team from the U.K.s Cell and Gene Therapy Catapult has been using digital tools to aid the manufacturing of autologous therapies, personalized to individual patients, as well as allogeneic therapies that treat a larger patient…...
Biomanufacturing Framework for Scaling and In-Line Monitoring
6+ hour, 7+ min ago (329+ words) The Biomanufacturing Training and Education Center at NC State University. [NC State University] A biomanufacturing framework addresses the challenges of scaleup and scaledown, enabling biomanufacturers to scale more quickly and efficiently, whether they're going from bench- to pilot-scale, or enhancing…...
Knowledge Graphs Tame Glycan Complexity
6+ hour, 7+ min ago (506+ words) Fragmented glycosylation evidence is transformed into a bioprocessing-ready knowledge graph, using text mining to link cell-culture parameters with glycan outcomes. This interactive interface reveals direct and indirect relationships for smarter process development. The post Knowledge Graphs Tame Glycan Complexity appeared…...
Fast Booming AI in Biopharma Needs Essential and Clear Regulations
6+ hour, 7+ min ago (506+ words) By Gareth John Macdonald Artificial intelligence (AI) is now an essential tool in biopharma manufacturing, yet industry still needs guidelines on how LLMs, ML, and other technologies should be used in drug making, say the authors of a new study....
Advancing Purification Standards for Oligonucleotide Manufacturing with Two-Dimensional Chromatography
1+ day, 1+ hour ago (760+ words) The successful application of RNA therapies to rare diseases, neurological disorders, and other conditions as well as the plethora of biopharmaceutical companies developing new RNA-based therapeutics, is driving regulators to update expectations for the purity of manufactured oligonucleotides used to…...
Complex DNA Written at Scale, Genyro Licenses Caltech’s Sidewinder
5+ day, 1+ hour ago (479+ words) Sidewinder achieves highly accurate assembly of long DNA sequences from scratch, offering a new leap forward for programmable biology By Fay Lin, PhD Adrian Woolfson, PhD, says biology is becoming a general design and manufacturing platform poised to unlock a…...
Ex-CEO Behind Bars, 10x’s Clinical Ambitions, Pharma’s AI Gambit
5+ day, 6+ hour ago (168+ words) By Alex Philippidis , Fay Lin, PhD , Uduak Thomas and Corinna Singleman, PhD Listed below are links to the GEN stories referenced in this episode of Touching Base: Ex-CytoDyn CEO Sentenced to 30-Month Prison Term on Fraud, Insider TradingBy Alex Philippidis,…...
DeepMind’s AlphaGenome Predicts Genetic Variation Function, Including Disease
6+ day, 4+ hour ago (516+ words) Small variations in DNA sequence can alter an organism's response to'the'environment or susceptibility to disease. Interpreting the impact of genome sequence variation remains a research challenge. Non-coding variants that lie outside of protein-coding regions are particularly difficult to interpret because…...
Barbados Government and BioMed X Partner to Improve AI-Based Early Diabetic Kidney Disease Modeling
6+ day, 10+ hour ago (193+ words) BioMed X, a Heidelberg, Germany-based innovation hub for pharma, launched its first research project in partnership with the Government of Barbados and with support from the European Union's PharmaNext Programme. The new global call for research proposals, entitled "AI-Enabled Therapy…...
No Pain, No Gain: Insilico 'Gym' Gets AI Models Into Shape
6+ day, 20+ hour ago (334+ words) Drug developer unveils domain-specific training infrastructure designed to enhance LLMs" ability to carry out drug discovery and development Insilico Medicine has launched Science MMAI Gym, a domain-specific training infrastructure designed to transform large language models (LLMs) into their best shape…...